Tetrahedron p. 4117 - 4126 (1993)
Update date:2022-08-05
Topics:
Gomez, Cecilia
Ramon, Diego J.
Yus, Miguel
The reaction of 3-chloro-2-chloromethylpropene (1) and carbonyl compounds (2) with an excess of lithium powder in the presence of a catalytic amount of naphthalene (6%) in tetrahydrofuran at -78 to 20°C leads, after hydrolysis, to the corresponding methylenic 1,5-diols 3 in a Barbier-type process. The treatment of the crude diols 3 with 12 M. hydrochloric acid affords selectively the corresponding substituted dihydropyrans 6.
View MoreContact:+86-021-6989-5597
Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China
Jiangxi Huashi Pharmaceutical Co., Ltd
Contact:+86-795-4509628
Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
website:http://www.chinabarton.com
Contact:+86-573-82719618
Address:No. 162 Fumin Road, Honghe Town,
Contact:+86-15995924277
Address:WuZhongOu suzhou new south road 89
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.
Contact:86-022-66880623
Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA
Doi:10.1021/jm3015052
(2013)Doi:10.1039/c2cc37537k
(2013)Doi:10.1039/c2cc37297e
(2013)Doi:10.1016/j.bmcl.2012.11.060
(2013)Doi:10.1021/jo5016008
(2014)Doi:10.1021/ol034299c
(2003)
