Highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones directed towards the synthesis of α-substituted β-amino acids

DOI: 10.1016/S0040-4039(00)79067-8

Source and publish data:

Tetrahedron Letters p. 2725 - 2728 (1992)

Update date:2022-08-04

Topics:

Authors:

Amoroso Amoroso

Cardillo

Tomasini

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Article abstract of DOI:10.1016/S0040-4039(00)79067-8

The highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones 1 and 2 has been reported. The corresponding lithium enolates have been alkylated under a variety of conditions with good trans selectivity and all the reaction products have been easily separated and characterised.

Full text of DOI:10.1016/S0040-4039(00)79067-8

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