Highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones directed towards the synthesis of α-substituted β-amino acids

DOI: 10.1016/S0040-4039(00)79067-8

Source and publish data:

Tetrahedron Letters p. 2725 - 2728 (1992)

Update date:2022-08-04

Topics:

Authors:

Amoroso Amoroso

Cardillo

Tomasini

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)79067-8

The highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones 1 and 2 has been reported. The corresponding lithium enolates have been alkylated under a variety of conditions with good trans selectivity and all the reaction products have been easily separated and characterised.

Full text of DOI:10.1016/S0040-4039(00)79067-8

Products guided by the article

Product name:(5R,6S)-5-Isobutyl-6-methyl-4-oxo-3-((S)-1-phenyl-ethyl)-tetrahydro-pyrimidine-1-carboxylic acid benzyl ester

Cas No:142055-37-6

R&D Labs maybe for 142055-37-6

FREEBARQUE DEVELOPMENT GROUP LIMITED

Contact:+86(0)10-5109 5335 or 5109 5345

Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Zhuhai Jiacheng Biological Technology Co., Ltd

Contact:0756-8800233

Address:room 222, Lianhua road , Gongbei ,Zhuhai, Guangdong ,China
Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd

Contact:86-0312-6615158

Address:No 42 fazhan street qingyuan county
lianyungang jinkang pharmaceutical technology co., ltd.

Contact:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China

Relevant to this article

Effective π-extension of carbazole-based thiaporphyrins by peripheral phenylethynyl substituents

Doi:10.1021/ol401403n
(2013)
Rhodium-catalyzed chemo- and regioselective cross-dimerization of two terminal alkynes

Doi:10.1021/ol303531m
(2013)
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: A natural product coupled approach to semicarbazones for antiepileptic activity

Doi:10.1016/j.bmcl.2012.11.051
(2013)
Iodine(III) Enabled Dehydrogenative Aryl C?S Coupling by in situ Generated Sulfenium Ion

Doi:10.1002/adsc.201801510
(2019)
Catalytic asymmetric protonation of silyl ketene imines

Doi:10.1021/ja312141b
(2013)
Efficient synthesis of bulky 4-substituted-isatins via microwave-promoted Suzuki cross-coupling reaction

Doi:10.1016/j.tetlet.2012.12.021
(2013)

Article Doi