Highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones directed towards the synthesis of α-substituted β-amino acids

Article abstract of DOI:10.1016/S0040-4039(00)79067-8

The highly diastereoselective alkylation of 6-methylperihydropyrimidin-4-ones 1 and 2 has been reported. The corresponding lithium enolates have been alkylated under a variety of conditions with good trans selectivity and all the reaction products have been easily separated and characterised.