Organic Process Research and Development p. 783 - 793 (2019)
Update date:2022-07-29
Topics:
St-Jean, Frédéric
Remarchuk, Travis
Angelaud, Rémy
Carrera, Diane E.
Beaudry, Danial
Malhotra, Sushant
McClory, Andrew
Kumar, Archana
Ohlenbusch, Gerd
Schuster, Andreas M.
Gosselin, Francis
A highly efficient and regioselective manufacturing route for the phosphoinositide 3-kinase β-sparing inhibitor taselisib was developed. Highlights of the synthesis include: (1) magnesium-mediated formation of a challenging cyclic amidine; (2) regioselect
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