The total synthesis of swinholide A. Part 1 : A stereocontrolled synthesis of a C19-C32 segment

DOI: 10.1016/0040-4020(95)00546-K

Source and publish data:

Tetrahedron p. 9393 - 9412 (1995)

Update date:2022-08-04

Topics:

Authors:

Paterson, Ian

Cumming, John G.

Ward, Richard A.

Lamboley, Serge

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Article abstract of DOI:10.1016/0040-4020(95)00546-K

The C₁₉-C₃₂ segment 10 of swinholide A was prepared in 15 steps (8% yield, 82% ds) from (±)-16. Key steps include (i) the Sharpless epoxidation, 16 → 17, (ii) the acetal allylation, 15 → 23, (iii) the anti aldol addition, 13 + 14 → 1

Full text of DOI:10.1016/0040-4020(95)00546-K

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