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(7) The double activation of the electrophilic substrate and the nucleꢀ
rial is available free of charge via the Internet at
ophilic reagent by the cooperative catalysis of two metal centers was
studied by Jacobsen, Shibasaki, our group and others. In those reacꢀ
tions the two separate metal centers play different roles – one center
activates the electrophilic substrate while the other center activates the
nucleophile, thereby facilitating the nucleophilic attack; For details on
such cooperative catalysis see: (a) Jacobsen, E. N. Acc. Chem. Res.
2000, 33, 421–431. (b) Yamamoto, H., Futatsugi, K. Angew. Chem.,
Int. Ed. 2005, 44, 1924–1942. (c) Shibasaki, M.; Kanai, M.; Matsunaꢀ
ga, S.; Kumagai, N. Acc. Chem. Res. 2009, 42, 1117–1127. (d) Kemꢀ
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AUTHOR INFORMATION
Corresponding Authors
*bhadra@isc.chubu.ac.jp
*hyamamoto@isc.chubu.ac.jp
Notes
per, S.; Hroba ́rik, P.; Kaupp, M.; Schlörer, N. E. J. Am. Chem. Soc.
No competing financial interests have been declared.
9
2009, 131, 4172–4173. (e) Zhang, Z.; Wang, Z.; Zhang, R., Ding, K.
Angew. Chem., Int. Ed. 2010, 49, 6746–6750. (f) Privileged Chiral
Ligands and Catalysts; Zhou. Q.ꢀL. Ed.; WileyꢀVCH: Weinheim,
Germany, 2011.
(8) Abell, J. P.; Yamamoto, H. Chem. Soc. Rev. 2010, 39, 61–69 and
references cited therein.
(9) The addition of measured quantity of water with anhydrous TBHP
shows comparable efficiency; see Table S1 in the SI.
(10) Hill, J. G.; Rossiter, B. E.; Sharpless, K. B. J. Org. Chem. 1983,
48, 3607–3608.
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ACKNOWLEDGMENTS
This work was supported by ACTꢀC, JST. We thank JSPS
for a postdoctoral fellowship to SB, and the Research Cenꢀ
ter for Computational Science, Okazaki, for the use of their
facility in our computational studies.
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