Chemical and Pharmaceutical Bulletin p. 846 - 850 (1992)
Update date:2022-09-26
Topics:
Ishikawa
Khachatrian
Melik-Ohanjanian
Kawahara
Mizuno
Ogura
7-Alkyl-1,3,6-trimethylpyrrolo[2,3-d]pyrimidine-2,4(1H,3H)-diones were readily synthesized by treatment of 6-alkylamino-5-allyl-1,3-dimethyluracils, which were derived from 5-allyl-6-chloro-1,3-dimethyluracil and alkylamines, with bis(acetonitrile) palladium (II) chloride. In addition, 4-alkylamino-2,5-dimethyl-2,3-dihydrofuro[3,2-e]pyrimidin-6-ones were easily synthesized by treatment of 5-allyl-6-chloro-1-methyluracil with alkylamines.
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