Hydrophilic pyrazine-based phosphane ligands: Synthesis and application in asymmetric hydride transfer and H2-hydrogenation of acetophenone

Article abstract of DOI:10.1016/j.tetlet.2013.01.108

Pyrazine-based hydrophilic phosphanes are useful ligands for the ruthenium- and rhodium-catalyzed hydrogenations of acetophenone under hydride transfer and dihydrogen conditions. The effect of alcohol additives on the catalytic, enantioselective aqueous h