Synthesis of 2,19-Bridged Androstenediones

DOI: 10.1021/jo00045a028

Source and publish data:

Journal of Organic Chemistry p. 5150 - 5154 (1992)

Update date:2022-08-02

Topics:

Authors:

Burkhart, Joseph P.

Huber, Edward W.

Laskovics, F. Mark

Peet, Norton P.

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Article abstract of DOI:10.1021/jo00045a028

The syntheses of 2,19-(methyleneoxy)androst-4-ene-3,17-dione (4a), a potent, time-dependent inhibitor of human placental aromatase, and its thio (4b), amino (5), and methylene (14) analogs are descibed.The key step in the construction of 4a, 4b, and 5 is

Full text of DOI:10.1021/jo00045a028

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