Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors

DOI: 10.1016/j.bmcl.2013.02.073

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2313 - 2318 (2013)

Update date:2022-07-31

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Authors:

Tang, Yan-Bo

Lu, Dianyun

Chen, Zheng

Hu, Chun

Yang, Ying

Tian, Jin-Ying

Ye, Fei Ye, Fei

Wu, Li Wu, Li

Zhang, Zhong-Yin

Xiao, Zhiyan

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Article abstract of DOI:10.1016/j.bmcl.2013.02.073

Fifteen novel sulfathiazole-related compounds were designed as PTP1B inhibitors based on a previously reported allosteric inhibitor (1) of PTP1B. These compounds were synthesized and evaluated against human recombinant PTP1B. Six compounds (3, 4, 8 and 14

Full text of DOI:10.1016/j.bmcl.2013.02.073

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