Some reactions of 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido) acetic acids

Article abstract of DOI:10.1080/00397911.2018.1489966

In situ generated 2,4-diaryl substituted münchnones from 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids react with acetic anhydride in the presence of 2-nitromethylene thiazolidine, which is most likely acting as a base, and une

Full text of DOI:10.1080/00397911.2018.1489966

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Some reactions of 2-(4-substitutedphenyl)-2-(N-
methyl-N-4-substitutedbenzamido) acetic acids
Yaşar Dürüst, Hamza Karakuş, Benson M. Kariuki & David W. Knight
To cite this article: Yaşar Dürüst, Hamza Karakuş, Benson M. Kariuki & David W. Knight (2018):
Some reactions of 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido) acetic acids,
Synthetic Communications, DOI: 10.1080/00397911.2018.1489966
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https://doi.org/10.1080/00397911.2018.1489966
Some reactions of 2-(4-substitutedphenyl)-2-(N-methyl-N-4-
substitutedbenzamido) acetic acids
a
, Hamza Karakus¸a, Benson M. Kariukib, and David W. Knightb
€ €
Yas¸ar Durust
a
b
_
Department of Chemistry, Abant Izzet Baysal University, Bolu, Turkey; School of Chemistry, Cardiff
University, Cardiff, UK
ABSTRACT
ARTICLE HISTORY
Received 23 March 2018
€
In situ generated 2,4-diaryl substituted munchnones from 2-(4-substi-
tutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids
KEYWORDS
react with acetic anhydride in the presence of 2-nitromethylene thia-
zolidine, which is most likely acting as a base, and unexpectedly
undergo a Dakin–West type reaction and a concurrent autoxidation
reaction leading to the formation of (E)-1-(N,4-dimethylbenzamido)-1-
(4-fluorophenyl)prop-1-en-2-yl acetate, 4-substitutedphenyl-N-methyl-
N-(4-substitutedbenzoyl) benzamides and p-substituted benzoic
acids. In addition, a novel and efficient access to N-acyl urea deriva-
tives is described by the reaction between 2-(4-substitutedphenyl)-2-
(N-methyl-N-4-substitutedbenzamido)acetic acids and cyclohexyl, iso-
propyl carbodiimides in the presence of a base. The structures of all
new products were identified on the basis of NMR and IR spectra,
along with X-ray diffraction data and HRMS measurements.
Acyl urea; Dakin–West
€
reaction; Munchnone
precursor; nitromethylene
thiazolidine
GRAPHICAL ABSTRACT
Introduction
€
Munchnones, so-called, 1,3-oxazolium-5-olates, are among the five-membered
mesoionic compounds which can be easily prepared by cyclodehydration of N-substi-
tuted-N-acyl-a-amino acids with acetic anhydride, N,N0-dicyclohexylcarbodiimide,
_
Department of Chemistry, Abant Izzet Baysal University, Bolu
€ €
CONTACT Yas¸ar Durust
yasardurust@ibu.edu.tr
14030, Turkey
Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lsyc.
Supplemental data for this article can be accessed on the publisher’s website.
ß 2018 Taylor & Francis

€ €
Y. DURUST ET AL.
2
Figure 1. Some biologically important imides and N-acylureas.
N,N0-diisopropylcarbodiimide and they are utilized in the synthesis of many valuable
heterocycles such as substituted pyrroles through 1,3-dipolar cycloaddition with a wide
range of doubly or triply bonded electron-deficient dipolarophilic reagents.[1–8] There
€
are many examples regarding the munchnones as 1,3-dipoles in cycloaddition reactions,
but other reactions of these ring systems have not been fully explored.
The Dakin–West reaction[9] is a well-known procedure for the preparation of espe-
cially a-acetamido methyl and b-aryl ketones, which are important skeletons of biologic-
ally or pharmacologically important compounds, by treatment of N-acylated a-amino
acids or aryl acetic acids with acetic anhydride or trifluoroacetic anhydride in the pres-
ence of a base.[10,11]
Imides in general are one of the most important structural motif for natural and
pharmaceutical compounds such as palau’imide,[12] coniothyriomycin,[13] ethosuxi-
mide,[14] fumaramidmycin,[15] and berkeleyamide B and C.[16] The N-acyl urea deriva-
tives are an important sub-class of such substrates especially for medicinal and
agrochemical applications. In addition, N-acylurea derivatives are used as inhibitors of
the reproduction and growth for the house fly and fall army worm (Figure 1).[17]
There are various methods to synthesize N-acylurea derivatives from the reactions of
carboxylic acids with carbodiimides.[18–20] Soeta and Ukaji have reported oxidative cou-
pling reaction of various kind of aldehydes with N,N0-disubstituted carbodiimides cata-
lyzed by N-heterocyclic carbene under aerobic conditions to furnish N-acyl derivatives.[21]
Taking account of the above considerations and literature-based knowledge of
€
munchnones, Dakin–West reaction which can be realized as a reaction pathway for our
work, we have focused on some reactions of the mu€nchnone precursors which have
turned out to be a practical one-pot protocol for the synthesis of N-acyl urea
derivatives.
Results and discussion
Recently, we have reported some chemistry incorporating mesoionic 1,3-dipoles; namely
sydnones, nitrile oxides, nitrile imines and electron-deficient alkenes, alkynes,[22]

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3
2-nitromethylenethiazolidine and benzothiophene 1,1-dioxide.[23–28] Herein, we report a
€
study of munchnones generated from 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitu-
tedbenzamido)acetic acids 3 and acetic anhydride, DCC and DIPC in the presence of
2-nitromethylenethiazolidine 4 and diisopropylamine. In this regard, the products were
one enol ester, five imides and seven benzoic acid derivatives obtained by the autoxida-
tion reaction between mu€nchnone precursors (amino acids) and acetic anhydride in the
presence of 2-nitromethylenethiazolidine. To the best of our knowledge, 2-nitromethyle-
nethiazolidine has not been reported so far as a base in such reactions, but in our case,
it might have behaved as a base through its imine tautomeric form. On the other hand,
N-acylureas derivatives have also been generated through a substitution reaction in
which 2-(4-substitutedphenyl)-2-(N-methyl-N-4-substitutedbenzamido)acetic acids
3
were interacted with dehydrating agents, DCC and DIPC in the presence of diisopropyl-
amine under reflux conditions in acetonitrile. There is no reported example for the syn-
thesis of N-acylureas from mu€nchnone precursors by means of N,N0-disubstituted
carbodiimides in the presence of a base.
4-Substituted N-methylgylcine hydrochloride 1a and 1 b play a key role in the
€
synthesis of unsymmetrical munchnone derivatives which were generated in situ from
C-(4-substitutedphenyl)-N-(benzoyl)-N-methylglycines 3a-k which were synthesized
according to the literature procedures[1–3] and used in the subsequent steps without fur-
ther purification.
2-(N,4-Dimethylbenzamido)-2-(4-fluorophenyl)acetic acid 3 b underwent a reaction
affording an enol ester 5 through a Dakin–West type transformation both in the pres-
ence of pyridine and 2-nitromethylene thiazolidine 4, but no reaction occurred under
microwave heating (Scheme 1). IR spectrum showed two carbonyl absorptions and pro-
ton NMR gave four singlet peaks between 3.31-1.98 ppm, one of them was of p-tolyl
methyl protons. After obtaining a fine crystal of the compound 5, we were able to
establish full structural characterization by means of X-ray diffraction data.
Other substituted amino acids 3 were tried under the same conditions for obtaining
derivatives of enol ester 5, but, amino acids 3a, 3ck have been found to be transformed
into imides 6d, 6f, 6i-k and 4-substituted benzoic acids 7a-g through sequential
Dakin–West and autoxidation reactions (Scheme 2). Huisgen and co-workers were first
to report the autooxidation of mu€nchnone generated from N-benzoyl-N-methyl phenyl-
glycine.[29] Also, Kawase investigated the autoxidation reaction of munchnones derived
€
from cyclic a-amino acids.[30] Although, in some cases, both structures (6 and 7) were
obtained, some of the reactions gave only one product (i.e. imides 6 or carboxylic acids
7) and also no 2-nitromethylenethiazolidine residue was detected along with
the products.
We began the reaction using amino acid 3 b (1 mmol): after addition of acetic
anhydride (3 mmol) and heated the mixture at 55ꢀC for 15 min 2-nitromethylenethia-
zolidine 4 was added and the resulting mixture heated at 90 ꢀC overnight. Only enol
ester 5 was obtained, possibly through a Dakin–West type reaction pathway at which
a tautomeric form of 2-nitromethylenethiazolidine might behaved as a base (Scheme
3). A similar product obtained through a rearrangement process with N-acyl prolines
in the presence of inorganic bases such as K2CO3, Na2CO3 was reported by the
Kawase group.[31]

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Y. DURUST ET AL.
4
Scheme 1. Reactions between 3b and acetic anhydride in the presence of 2-nitromethylenethiazoli-
dine 4 and pyridine to afford enol ester 5.
We have utilized the same reaction conditions for other amino acids (3a-k) to obtain
a variety of enol esters 5, but all the attempts failed, that is, no ester products
were formed.
In order to provide a full characterization of the structure, an X-ray ORTEP view for
enol ester 5 was obtained (Figure 2).
However, when the compounds 3d, 3f, 3i-k were used as starting aminoacids, some
new benzoyl, methyl substituted benzamides 6d, 6f, 6i-k were obtained as the only
products. IR spectra of the products showed two carbonyl absorption bands. Since pro-
ton NMR spectra did not give four singlet peaks as in compound 5 and only one singlet
peak appeared at approximately 3.50 ppm (N-CH3), we concluded that these products
were the imides 6. A possible reaction mechanism can be proposed in which, after
mu€nchnone formation, the ketene is likely attacked by a water molecule and a subse-
quent release of carbon dioxide may be considered (Scheme 4).
Formation of similar imides, but not exactly the same, through peroxidation of C-H
bonds in amides, via the reaction of nitrones with aroyl chlorides; imidoyl chlorides
with phenols and by thermal transformations of oxazole endoperoxides has been
reported.[32–37] We used the amino acids (3d, 3f, 3i-k) and obtained similar proton and
carbon NMR resonances for the products.
We were able to establish exact structure of 6d by X-ray diffraction data (Figure 3).
In some cases, the carboxylic acids 7 were obtained possibly via a mechanism
depicted below (Scheme 5).
In order to identify the carboxylic acid formed above reaction exactly, X-Ray diffrac-
tion data of 4-trifluoromethylbenzoic acid 7f was obtained using a fine crystal of it

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SYNTHETIC COMMUNICATIONSV
5
€
Scheme 2. The reaction between munchnone precursors 3 and acetic anhydride in the presence of
2-nitromethylenethiazolidine 4.
(Figure 4). Finger print region in the IR spectrum of 7f is exactly same with the one of
euthentic sample.
In order to rationalize whether aromatic substituent on nitrogen affects the product
formation, we used N-acetyl substituted amino acid 3 h both under classical and micro-
wave heating conditions and observed no reaction at all, confirming that aromatic
group has the major impact on this reaction.
Then, mu€nchnone precursors 3 were reacted both with cyclohexyl and isopropyl car-
bodiimides in the presence of diisopropyl amine and a series of urea derivatives 9, 11
have been obtained. Their IR spectra showed two carbonyl absorptions between 1720

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Y. DURUST ET AL.
6
Scheme 3. Formation of enol ester 5.
Figure 2. X-Ray ORTEP view of enol ester 5.
and 1690 cmꢁ1. Also, proton NMR spectra showed one singlet signal between 6.70 and
6.00 ppm, two multiplet peaks between 4.50 and 3.75 ppm (Figure 5). These spectral
data were not enough for full structural characterization of these compounds. But, how-
ever, we were able to obtain fine crystals of the compound 11e. X-ray diffraction
ORTEP view which confirmed the structures is shown (Scheme 6, Figure 6
On the basis of these results, we were able to write a Dakin–West type reaction
mechanism for the formation of N-acylurea products. Thus, initially, N-acylamino acids
3 reacted with carbodiimides to give a mesoionic 1,3-oxazolium-5-olate form which
may be in equilibrium with ketene whose formation could be facilitated by the elevated
temperature of refluxing acetonitrile.

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7
Scheme 4. Possible reaction mechanism involving an autoxidation pathway leading to N-acyl amides
6d, 6f, 6i-k.
Figure 3. X-Ray ORTEP view of 6d.

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Y. DURUST ET AL.
8
Scheme 5. Possible reaction mechanism leading to 4-substituted benzoic acids 7a-g.
Figure 4. X-Ray ORTEP view of 7f.
Figure 5. 1H NMR spectra of 9d and 11g.

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SYNTHETIC COMMUNICATIONSV
9
€
Scheme 6. Reactions of munchnone precursors 3 with diisopropyl carbodiimide (DIPC) 8 and dicy-
clohexyl carbodiimide (DCC) 10 in the presence of diisopropyl amine (DIPA) to afford 9a-f and
11a-g. Reagents and solvent:
3 (0.47 mmol), 8 (3.0mL), 10 (1.91 mmol), DIPA (0.2 mL),
CH3CN (10.0 mL).
Figure 6. X-Ray ORTEP view of 11e.
Then, amide carbonyl was attacked by OH– later converted to carboxylic acid 7 and
formyl imine which could not be detected or isolated. Finally, excess carbodiimide
underwent a reaction with carboxylic acid 7, namely, acyl transfer leads to the corre-
sponding N-acylureas 9 and 11 (Scheme 7).

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Y. DURUST ET AL.
10
Scheme 7. A plausible reaction mechanism leading to N-acylureas 9 and 11.
Conclusion
In summary, we demonstrated that a Dakin–West type transformation and autoxidation
€
reaction occur in the interactions between munchnone precursors (amino acids) and
acetic anhydride in the presence of 2-nitromethylenethiazolidine which likely acts as a
base through its enamine tautomer to afford an enol ester; (E)-1-(N,4-dimethylbenza-
mido)-1-(4-fluorophenyl)prop-1-en-2-yl acetate 5, 4-substituted-N-methyl-N-(4-substitu-
tedbenzoyl)benzamides 6 and substituted benzoic acids 7. A plausible mechanism where
mu€nchnones are being converted into imides through an autoxidation process was pro-
posed. In addition, we introduced a novel, efficient and one-pot protocol to give N-acy-
lurea derivatives 9 and 11 through the reaction between mu€nchnone precursors with
carbodiimides in the presence of a base. This reaction sequence demonstrates the influ-
ence of the carbodiimides both as a dehydrating agent and a reactant.
€
Experimental: Reactions between munchnone precursors 3a-k and acetic
anhydride in the presence of 2-nitromethylenethiazolidine 4
General procedure
Route A
Synthesis of E-1-(N,4-dimethylbenzamido)-1-(4-fluorophenyl)prop-1-en-2-yl acetate 5: 2-
(N,4-Dimethylbenzamido)-2-(4-fluorophenyl)acetic acid 3 b (2.80 mmol, 806 mg) was

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11
heated in acetic anhydride (8 mL) at 55 ꢀC for 30 min. Then, 2-(nitromethylene) thiazo-
lidine 4 (1.00 mmol, 146 mg) was added to the reaction mixture and refluxed overnight
at 90 ꢀC. After cooling the reaction mixture to room temperature, the solvent was
removed under the reduced pressure and the crude residue was purified by flash col-
umn chromatography (silica gel, EtOAc/n-hexane; 1:7) to give 5 as yellow solid. Yieꢁld1:
48%; mp 98–100 ꢀC. IR (KBr): ꢀ ¼ 2958, 1745, 1647, 1508, 1358, 1217, 1082, 839 cm
.
1 H NMR (400 MHz, CDCl3): d 7.27 (d, J ¼ 8.1 Hz, 2H), 7.13–7.10 (m, 2H), 7.01 (d,
J ¼ 7.9 Hz, 2H), 6.90 (t, J ¼ 8.7 Hz, 2H), 3.31 (s, 3H), 2.30 (s, 3H), 1.98 (d, J ¼ 4.8 Hz,
6H). 13 C NMR (100 MHz, CDCl3): d 171.6, 168.6, 162.0 (d, C-F carbon, J ¼ 247.0 Hz),
144.7, 140.4, 132.6 (d, b-C to C-F, Jmeta= 18.0 Hz), 131.2, 129.4, 129.3, 128.4, 127.5,
115.2 (d, a-C to C-F, Jortho= 22.0 Hz), 37.2, 21.4, 20.9, 17.3. LC-MS (ESþ) m/z (%):
342.2 [M þ H]þ. HRMS: m/z (ESI-TOF, [M þ H]þ) calcd for C20H20FNO3: 342.1505.
Found: 342.1500.
Route B
4-Chlorobenzoic acid 7e: 2-(4-Chloro-N-methylbenzamido)-2-(4-fluorophenyl)acetic acid
3e (0.715 mmol, 230 mg) in acetic anhydride (2.23 mL) was irradiated at 0–150 W for
15 min in closed glass vial in a CEM Discover microwave reactor at 55 ꢀC. Then, 2-
(nitromethylene)thiazolidine 4 (0.255 mmol, 38 mg) was added the reaction mixture and
irradiated at 0-150 W for further 45 min at 80 ꢀC. After cooling the reaction mixture to
room temperature, the solvent was removed under the reduced pressure and the residue
was purified by flash column chromatography (silica gel, EtOAc/n-hexane;1:18) to
give 7e.
4-Fluoro-N-methyl-N-(4-nitrobenzoyl)benzamide 6d (route a): Yellow solid. Yield:
34%; mp 131-133 ꢀC. IR (KBr): ꢀ ¼ 3117, 1701, 1651, 1600, 1519, 1342, 1288, 1041,
852 cmꢁ1
.
1 H NMR (400 MHz, CDCl3): d 8.10 (d, J ¼ 8.0 Hz, 2H), 7.62-7.56 (m, 4H),
7.00 (t, J ¼ 8.0 Hz, 2H), 3.50 (s, 3H). 13 C NMR (100 MHz, CDCl3): d 172.9, 171.9,
165.3 (d, C-F carbon, J ¼ 154.0 Hz), 149.2, 141.6, 131.7 (d, b-C to C-F, Jmeta= 9.0 Hz),
131.1, 129.3, 123.7, 116.2 (d, a-C to C-F, Jortho= 22.0 Hz), 34.6. LC-MS (ESþ) m/z (%):
297 [M-4H]þ. Calculated for C15H11FN2O4; 302.0703; C, 59.61; H, 3.67; N, 9.27. Found:
C, 59.84; H, 3.84; N, 9.22.
4-Chlorobenzoic acid 7e (route a and route B): White solid. Yield: 83%; mp 235-
237 ꢀC (lit.[38,39] mp 236-237 ꢀC). IR (KBr): ꢀ ¼ 3093, 1685, 1593, 1423, 1280, 1176,
1091, 759 cmꢁ1
.
1 H NMR (400 MHz, DMSO-d6): d 13.1 (s, 1H), 7.90 (dd, J ¼ 8.0,
4.0 Hz, 2H), 7.53 (d, J ¼ 8.0, 4.0 Hz, 2H). 13 C NMR (100 MHz, DMSO-d6): d 169.9,
138.3, 131.7, 130.2, 129.3. LC-MS (ES-) m/z (%): 155 [M-H]-.
General procedure
Synthesis of 4-substituted-N-isopropyl-N-(isopropylcarbamoyl)benzamides 9a-f
and 4-substituted-N-cyclohexyl-N-(cyclohexylcarbamoyl)benzamides 11a-g
2-(4-Chloro-N-methylbenzamido)-2-(4-fluorophenyl) acetic acid 3e (0.47 mmol, 151 mg)
was dissolved in acetonitrile (10 mL) and DIPC (diisopropyl carbodiimide) 8 (0.3 mL)
was added. Then, the reaction mixture was heated at 55 ꢀC for 30 min. Then, DIPA

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Y. DURUST ET AL.
12
(diisopropyl amine) (0.2 mL) was added and refluxed overnight at 90 ꢀC. After cooling
the reaction to room temperature, the solvent was removed under vacuum and the resi-
due was purified by flash column chromatography (silica gel, EtOAc/n-hexane;1:8) to
give 9a-f and when DCC (dicyclohexylcarbodiimide) was used at the same reaction con-
ditions and molar amounts of reagents, the compounds 11a-g were obtained
(Scheme 6).
N-isopropyl-N-(isopropylcarbamoyl)-4-chlorobenzamide 9d
White solid. Yield: 50%; mp 154–156 ꢀC. IR (KBr): ꢀ ¼ 3321, 2974, 1705, 1631, 1546,
1373, 1257, 1091, 833 cmꢁ1
.
1 H NMR (400 MHz, CDCl3): d 7.46 (d, J ¼ 8.4 Hz, 2H),
7.39 (d, J ¼ 8.5 Hz, 2H), 6.57 (s, 1 H, NH), 4.42–4.32 (m, 1H), 3.88–3.78 (m, 1H), 1.41
(d, J ¼ 6.8 Hz, 6H), 1.00 (d, J ¼ 6.6 Hz, 6H). 13 C NMR (100 MHz, CDCl3): d 171.0,
153.9, 136.9, 135.4, 128.9, 127.9, 50.3, 42.8, 22.3, 20.9. LC-MS (ES-) m/z (%): 281.3 [M-
H]-, 326.9 [M þ Na þ CH3CN]. HRMS: m/z (ESI-TOF, [M þ H]þ) calcd for
C20H20FNO3: 342.1505. Found: 342.1500.
N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-chlorobenzamide 11d
White solid. Yield: 75%; mp 181–183 ꢀC. (lit.[21] mp 183.1–183.3 ꢀC). IR (KBr):
ꢀ ¼ 3306, 2931, 1701, 1647, 1543, 1342, 1234, 1087, 833 cmꢁ1
.
1 H NMR (400 MHz,
CDCl3): d 7.49 (d, J ¼ 8.4 Hz, 2H), 7.37 (d, J ¼ 8.4 Hz, 2H), 6.08 (s, 1H), 4.10–4.02 (m,
1H), 3.54–3.46 (m, 1H), 2.08–1.95 (m, 2H), 1.81–1.77 (m, 4H), 1.65–1.51 (m, 5H),
1.32–1.04 (m, 7H), 0.91 (dd, J ¼ 24.1, 13.0 Hz, 2H). 13 C NMR (100 MHz, CDCl3): d
170.1, 154.0, 135.3, 130.0, 128.8, 128.2, 57.5, 49.7, 32.3, 30.8, 26.2, 25.3, 25.2, 24.5. LC-
MS (ES-) m/z (%): 363.6 [M þ H]þ.
Funding
€ _
TUBITAK (Turkish Scientific and Technological Research Council, grant no. [211T037]) is grate-
fully acknowledged for financial support.
ORCID
€ €
Ya¸sar Durust
http://orcid.org/0000-0002-0873-694X
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