Synthesis p. 558 - 561 (1992)
Update date:2022-07-30
Topics: Cyanide source Workup Reaction Conditions Palladium catalyst Base
Hosokawa
Aoki
Murahashi
α-Cyanoallyl acetate (1 a), when treated with methanol in the presence of bis(acetonitrile)dichloropalladium(II) catalyst, is acetalized at the terminal olefinic carbon to give 1-cyano-3,3-dimethoxypropyl acetate (2). γ-Substituted α-cyanoallyl acetates give 3-substituted 1-cyano-3-oxo-propyl acetates 5 from which 2-cyanovinyl ketones 11 are obtained in good yields.
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