Thromboxane Receptor Antagonism Combined with Thromboxane Synthase Inhibition. 5. Synthesis and Evaluation of Enantiomers of 8-amino>-4-(3-pyridinylalkyl)octanoic Acid

DOI: 10.1021/jm00054a003

Source and publish data:

Journal of Medicinal Chemistry p. 205 - 210 (1993)

Update date:2022-09-26

Topics:

Authors:

Bhagwat, Shripad S.

Gude, Candido

Cohen, David S.

Dotson, Ron

Mathis, Janice

et al. et al.

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Article abstract of DOI:10.1021/jm00054a003

The enantiomers of 8-<<(4-chlorophenyl)sulfonyl>amino>-4-(3-pyridinylpropyl)octanoic acid (1) and its pyridinyl ether analog (2) were synthesized using the highly diastereoselective method of alkylation of acyloxazolidinone.These enantiomerically pure com

Full text of DOI:10.1021/jm00054a003

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