An optically pure 1,4-dihydropyridine from a resolution catalysed by rabbit liver esterase

DOI: 10.1016/S0957-4166(00)80520-0

Source and publish data:

Tetrahedron Asymmetry p. 785 - 794 (1992)

Update date:2022-09-26

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Authors:

Reeve Reeve

Crout Crout

Cooper Cooper

Fray Fray

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Article abstract of DOI:10.1016/S0957-4166(00)80520-0

The kinetic resolution of the precursor of the dihydropyridine UK-74,505, 1, an antagonist of platelet activating factor, is described, in which rabbit liver esterase was used to catalyse the hydrolysis of an ester function linked to the chiral centre via

Full text of DOI:10.1016/S0957-4166(00)80520-0

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Product name:4-(2-chlorophenyl)-1,4-dihydro-3-ethoxycarbonyl-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>pyridine-5-methoxycarbonylethylcarboxylate

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