Facile Chlorination of Sugar Moiety of Nucleosides by Use of Tris(2,4,6-tribromophenoxy)dichlorophosphorane

DOI: 10.1246/cl.1992.1505

Source and publish data:

Chemistry Letters p. 1505 - 1506 (1992)

Update date:2022-08-03

Topics: Yield Solvent Chlorination Stirring Filtration Nucleosides Sugar moiety Facile Reaction Vessel Reactant

Authors:

Ohuchi, Shokichi

Singh, Ramendra K.

Wada, Takeshi

Hata, Tsujiaki

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Article abstract of DOI:10.1246/cl.1992.1505

A versatile chlorinating reagent, tris(2,4,6-tribromophenoxy)dichlorophosphorane was applied for 5'- and 3'-chlorination of nucleosides.It was found that the reaction proceeded via S_N2 mechanism.

Full text of DOI:10.1246/cl.1992.1505

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