Stereocontrolled Synthesis of C2-Symmetric and Pseudo-C2-Symmetric Diamino Alcohols and Diols for Use in HIV Protease Inhibitors

Article abstract of DOI:10.1021/jo00047a023

The stereocontrolled syntheses of dibenzyldiamino alcohol 1 and dibenzyldiamino diols 2-4, core units of potent C₂-symmetric and pseudo-C₂-symmetric inhibitors of HIV protease, are described, starting from phenylalanine.Stereoselecti