Design and Evaluation of a Tightly Binding Fluorescent Ligand for Influenza A Haemagglutinin

Article abstract of DOI:10.1021/ja00050a004

Attachment of influenza virus to susceptible cells is mediated by the viral protein hemagglutinin, which recognizes cell-membrane-bound glyconjugates that terminate in α-sioalosides.We have synthesized a fluorescent α-sialoside that has the highest affini