Synthesis of three new carbocyclic analogues of 3'-deoxy purine ribonucleosides

Article abstract of DOI:10.1080/15257779408011885

The 1-hydroxymethyl-3-cyclopentene (4) was converted, after epoxidation, to two new exocyclic amino carbocyclic nucleosides (1, 2), and a new cyclopentane nucleoside analogue (3), with potential biological activities. The regioselectivity of the epoxidation (4), which is the key step, is governed by steric control using aryl and silyl hydroxyl protecting groups.

Full text of DOI:10.1080/15257779408011885

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Nucleosides and Nucleotides
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Synthesis of Three New Carbocyclic
Analogues of 3′-Deoxy Purine
Ribonucleosides
Luigi Agrofoglio a c , Roger Condom a , Roger Guedj a , S. Richard
Challand b & John Selway b
a Laboratoire de Chimie Bio-Organique. UNSA, Faculté des Sciences ,
BP. 71, F - 06108, Nice, CEDEX, 2, France
b Wellcome Research Laboratories, Langley Court , Beckenham,
Kent, BR3 3BS, Great Britain
c The University of Alabama at Birmingham, Department of
Pharmacology , 111 Volker Hall. 1670 University Blvd, Birmingham,
Alabama, 35294-0019, USA
Published online: 24 Sep 2006.
To cite this article: Luigi Agrofoglio , Roger Condom , Roger Guedj , S. Richard Challand & John
Selway (1994) Synthesis of Three New Carbocyclic Analogues of 3′-Deoxy Purine Ribonucleosides,
Nucleosides and Nucleotides, 13:5, 1147-1160, DOI: 10.1080/15257779408011885
To link to this article: http://dx.doi.org/10.1080/15257779408011885
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