1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies

DOI: 10.1016/j.bmc.2013.04.074

Source and publish data:

Bioorganic and Medicinal Chemistry p. 4288 - 4295 (2013)

Update date:2022-08-05

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Authors:

Kaur, Jatinder

Bhardwaj, Atul

Sharma, Sai Kiran

Wuest, Frank

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Article abstract of DOI:10.1016/j.bmc.2013.04.074

A novel group of 1,4-diaryl-substituted triazoles was designed and synthesized by introducing the cyclooxygenase-2 (COX-2) pharmacophore SO ₂NH₂ attached to one aryl ring and various substituents (H, F, Cl, CH₃ or OCH

Full text of DOI:10.1016/j.bmc.2013.04.074

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