The invention of radical reactions. Part XXV. A convenient method for the synthesis of the acyl derivatives of N-hydroxypyridine-2-thione

Article abstract of DOI:10.1016/S0040-4020(01)88249-1

Treatment of the readily available di-N-oxide - of 2-thiopyridine disulfide 6 with tributylphosphine in the presence of a carboxylic acid provides a convenient and high yielding synthesis of the acyl derivatives 2 of N-hydroxy-2-thio-pyridone. Application of this procedure to the acids 17 and 18 gave, after irradiation in the presence of t-butylthill, the desired decarboxylated derivatives in high (>90%) yield.