Simplified synthesis of peptides with non-protected amino acid hydrochlorides via four-component condensation

Article abstract of DOI:10.1055/s-1992-26240

Synthesis of sulfur containing peptide analogues, 3-(ω-aminoalkanoyl)-2,2-dimethyl-1,3-thiazolidine-4-carboxamides 2, via Ugi four-component condensation (4CC) starting from 2,5-dihydro-1,3-thiazoles 1, isocyanides and non-protected amino acid hydrochlori