Synthesis of 3'-alkylthio-2',3'-dideoxy nucleosides with potential anti-HIV activity from 2-deoxy-D-ribose, using a phosphorus pentoxide reagent

Article abstract of DOI:10.1002/ardp.19923250914

Direct condensation of 2-deoxy-D-ribose (1) with mercaptans using the P₄O₁₀/H₂O/Bu₃N reagent in chloroform resulted in coupling at C-3 to give the anomeric mixtures of the corresponding pentopyranoses 2 and pent