Enzyme-catalysed Hydrolysis of Dimethyl 7-Hydroxy-3,3-dimethyl-2,4-dioxabicyclooctane-6,8-dicarboxylate and a Novel Synthesis of Neplanocin A

DOI: 10.1039/P19920002245

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2245 - 2246 (1992)

Update date:2022-08-04

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Authors:

Hutchinson, Edward J.

Roberts, Stanley M.

Thorpe, Andrew J.

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Article abstract of DOI:10.1039/P19920002245

Hydrolysis of the diester 1 catalysed by pig liver esterase provided the mono-ester 3.This ester was converted into the amine 9, a precursor of neplanocin 10, thereby confirming the previously proposed configuration of 3.

Full text of DOI:10.1039/P19920002245

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