Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases

DOI: 10.1016/j.bmcl.2013.12.020

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 565 - 570 (2014)

Update date:2022-09-26

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Authors:

Kato, Yuko

Fuchi, Nobuhiro

Nishimura, Yutaka

Watanabe, Ayano

Yagi, Mai

Nakadera, Yasuhito

Higashi, Eriko

Yamada, Masateru

Aoki, Takumi

Kigoshi, Hideo

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Article abstract of DOI:10.1016/j.bmcl.2013.12.020

We identified 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted ureas as highly potent soluble epoxide hydrolase (sEH) inhibitors and orally active agents for treating chronic kidney diseases. Compound 19 exhibited excellent sEH inhibitory activity a

Full text of DOI:10.1016/j.bmcl.2013.12.020

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