THE MICROBIOLOGICAL TRANSFORMATION OF SOME ENT-7α,15β-DIHYDROXYKAURENE DERIVATIVES BY GIBBERELLA FUJIKUROI

Article abstract of DOI:10.1016/0031-9422(91)85102-6

The microbiological transformation by the fungus Gibberella fujikuroi of ent-7α,15β-dihydroxy-kaur-16-ene gave ent-7α,15β,19-trihydroxy-kaur-16-ene, ent-7α,11α,15β-trihydroxykaur-16-ene, ent-7α,11α,15β,16β,17-pentahydroxy-kaurane and ent-7α,11α,13,15β-tetrahydroxy-kaur-16-ene. ent-7α,15β,18-Trihydroxy-kaur-16-ene (eubotriol) afforded ent-7α,11α,15β,18-tetrahydroxy-kaur-16-ene, ent-7α,15β,18,19-tetrahydroxy-kaur-16-ene, ent-7α,17,18-trihydroxy-15β,16β-epoxy-kaurane (epoxysideritriol), and ent-7α,17,18,19-tetrahydroxy-kaur-15-ene.The last three compounds were identified as their acetate derivatives.Key Word Index - Gibberella fujikuroi; microbiological transformations; diterpenes; ent-7α,15β-dihydroxy-kaur-16-ene; eubotriol.