Anellated pyridine compounds from hydrocodone and oxycodone, II: Diepoxy-bis-(iminoethano)-dinaphth[2,1-b:1',2'-i]acridines

Article abstract of DOI:10.1002/ardp.19923251004

Michael addition of hydrocodone (1a) or oxycodone (1b) with their 7-benzylidene compounds 2 yields the enol half ketales 3. The 1,4-dihydropyridines 4 are obtained by heating 3 with ammonium acetate in acetic acid. 4d is prepared from 1b and 2b with ammon