Preparation of optically active succinic acid derivatives: I. Optical resolution of 2-benzyl-3-(cis-hexahydroisoindolin-2-ylcarbonyl)-propionic acid

DOI: 10.1248/cpb.45.1518

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1518 - 1520 (1997)

Update date:2022-08-04

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Authors:

Yamaguchi, Toshiaki

Yanagi, Takashi

Hokari, Hiroshi

Mukaiyama, Yuko

Kamijo, Tetsuhide

Yamamoto, Iwao

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Article abstract of DOI:10.1248/cpb.45.1518

(+)-Monocalcium bis[(2S)-2-benzyl-3-(cis-hexahydroisoindolin-2- ylcarbonyl)propionate] dihydrate (KAD-1229, 1) is an optically active succinic acid calcium salt derivative with potent hypoglycemic effect. We investigated two optical resolution method. 2-B

Full text of DOI:10.1248/cpb.45.1518

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