Synthetic approaches toward total synthesis of 12β-methyl- and 12-methylene-19-norpregnanes

Article abstract of DOI:10.1016/0039-128X(92)90020-A

The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12β-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17β-hydroxy-12β-methyl-18a-