Total synthesis of chelerythrine, a benzo[c]phenanthridine alkaloid

DOI: 10.1248/cpb.40.2002

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2002 - 2006 (1992)

Update date:2022-09-26

Topics:

Authors:

Ishii Ishii

Ishikawa

Takeda Takeda

Suzuki Suzuki

Harayaya

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Article abstract of DOI:10.1248/cpb.40.2002

By taking advantage of our novel synthetic methods involving CsF-mediated Claisen rearrangement of an aryl propargyl ether to a 2-methylbenzolfuran and oxidative cleavage of the furan ring to a salicylaldehyde, total synthesis of chelerythrine, a benzo[c]phenanthridine alkaloid, was accomplished via the common intermediate (5) prepared through the two routes shown in Chart 3.

Full text of DOI:10.1248/cpb.40.2002

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