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| CAS No.: | 59-30-3 |
|---|---|
| Name: | Folic acid |
| Molecular Structure: | |
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|
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| Formula: | C19H19N7O6 |
| Molecular Weight: | 441.403 |
| Synonyms: | 4-Pteridinol, 2-amino-6-((p-((1, 3-dicarboxypropyl)carbamoyl)anilino)methyl)-;Acido folico [INN-Spanish];Folsav;(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-7-yl)methylamino]benzoyl]amino]pentanedioate;Vitamin M;Pteroyl-L-monoglutamic acid;Folvite;Folaemin [Netherlands];L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-;Folico (Italy);pteridinyl)methyl]amino]benzoyl]-;Kyselina listova [Czech];Folettes;Folipac;Foliamin;(2R)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;Folasic (Australia);Incafolic;L-Glutamic acid,N-[4-[[(2-amino-1,4- dihydro-4-oxo-6-pteridinyl)methyl]amino]- benzoyl]-;Glutamic acid, pteroyl-, L-;Folic acid (TN);L-glutamic acid, N-[4-[[(2-amino-4,8-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;Vitamin Be;(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;Pteroylmonoglutamate;Glutamic acid, N-[p-[[(2-amino-4-hydroxypyrimido(4, 5-b)pyrazin-6-yl)methyl]amino]benzoyl]-, L;L-Glutamic acid, N-(4-(((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, K salt;Folate;Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-;Folacin;Vitamin B9; |
| EINECS: | 200-419-0 |
| Density: | 1.68 g/cm3 |
| Melting Point: | 250 °C |
| Boiling Point: | 552.35°C (rough estimate) |
| Solubility: | 1.6 mg/L (25 °C) in water |
| Appearance: | orange to yellow crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 33-62-68 |
| Safety: | 24/25 |
| PSA: | 213.28000 |
| LogP: | 1.00030 |
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- 894852-01-87-BROMO-2,2-DIMETHYL-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
| Conditions | Yield |
|---|---|
| With 1,1,1-trichloroacetone; sodium sulfite In water at 40 - 50℃; for 1h; pH=3 - 4; pH-value; Temperature; | 85% |
- 921-03-9
1,1,3-trichloroacetone
- 4271-30-1
N-(4-aminobenzoyl)-L-glutamic acid
- 35011-47-3
2,4,5-triamino-6-hydroxypyrimidine sulfate
- 59-30-3
folate
| Conditions | Yield |
|---|---|
| With sodium metabisulfite at 20 - 30℃; for 2h; Temperature; Ionic liquid; | 83.2% |
| With sodium metabisulfite; sodium acetate at 45℃; for 3h; Temperature; | 46.2% |
- 918-00-3
1,1,1-trichloroacetone
- 6758-40-3
p-Nitrobenzoyl-L-(+)-glutamic acid
- 2387-48-6
2,4-diamino-5-nitroso-6-hydroxypyrimidine
- 59-30-3
folate
| Conditions | Yield |
|---|---|
| Stage #1: p-Nitrobenzoyl-L-(+)-glutamic acid; 2,4-diamino6-hydroxy-5-nitroso pyrimidine With hydrogen In water at 82℃; under 6000.6 Torr; Stage #2: 1,1,1-trichloroacetone With sodium metabisulfite; sodium hydroxide In water at 45℃; pH=4.5; pH-value; Pressure; Temperature; | 80% |
- 918-00-3
1,1,1-trichloroacetone
- 4271-30-1
N-(4-aminobenzoyl)-L-glutamic acid
- 35011-47-3
2,4,5-triamino-6-hydroxypyrimidine sulfate
- 59-30-3
folate
| Conditions | Yield |
|---|---|
| Stage #1: 1,1,1-trichloroacetone; N-(4-aminobenzoyl)-L-glutamic acid With sodium acetate; sodium sulfite In acetic acid at 43℃; for 0.5h; Stage #2: 2,4,5-triamino-6-hydroxypyrimidine sulfate In acetic acid at 38℃; for 5h; | 75.5% |
- 3475-39-6
1,1,3-tribromoacetone
- 4271-30-1
N-(4-aminobenzoyl)-L-glutamic acid
- 35011-47-3
2,4,5-triamino-6-hydroxypyrimidine sulfate
- 59-30-3
folate
| Conditions | Yield |
|---|---|
| With sodium carbonate In ethanol; water at 40℃; pH=7.5; Temperature; pH-value; | 60% |
- 65165-92-6
folate
- 497-15-4
2-hydroxy-3-oxopropionaldehyde
- 4271-30-1
N-(4-aminobenzoyl)-L-glutamic acid
- 59-30-3
folate
| Conditions | Yield |
|---|---|
| With sodium hydroxide |
| Conditions | Yield |
|---|---|
| In water |
- 59-30-3
folate
- 485800-26-8
N-tert-butoxycarbonyl cystamine
- 1301165-94-5
tert-butyl 2-{[2-({N2-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)-N1-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}dithio)ethyl]-α-glutaminyl}amino)ethyl]dithio}ethylcarbamate
| Conditions | Yield |
|---|---|
| With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 100℃; | 96% |
| Conditions | Yield |
|---|---|
| Stage #1: folate With sodium hydroxide at 50℃; for 2h; pH=7.4; Stage #2: calcium chloride In ethanol; water at 50℃; for 1h; | 96% |
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- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
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Chemistry
The Structure of Folic Acid (CAS NO.59-30-3):
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IUPAC Name: 2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
Molecular formula: C19H19N7O6
Molar mass: 441.4 g mol-1
H bond acceptors: 13
H bond donors: 7
Freely Rotating Bonds: 9
Polar Surface Area: 137.84Å2
Index of Refraction: 1.762
Molar Refractivity: 107.81 cm3
Molar Volume: 261.3 cm3
Surface Tension: 80.6 dyne/cm
Density: 1.68 g/cm3
Melting Point: 250 °C
Storage Temp: 2-8°C
Water Solubility: 1.6 mg/L (25 ºC)
Stability: Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive
EINECS: 200-419-0
Product Categories: Food and Feed Additive; Biochemistry; Vitamins; Nutritional Supplements; Vitamin Ingredients
InChI
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
Smiles
c12c(nc(CNc3ccc(C(N[C@@H](CCC(O)=O)C(O)=O)=O)cc3)cn1)c(nc([nH]2)N)=O
History
Folic Acid (CAS NO.59-30-3) was identified as the corrective substance in brewer's yeast in the late 1930s and was first isolated in spinach leaves by Mitchell and others in 1941.
Uses
Folic Acid (CAS NO.59-30-3) is necessary for the production and maintenance of new cells, appears to reduce the risk of stroke. It is also added to grain products in many countries and in these countries fortified products make up a significant source of folate. It is an important nutrient for women who may become pregnant.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 120mg/kg (120mg/kg) | Drugs in Japan Vol. -, Pg. 1409, 1995. | |
| mouse | LD50 | intraperitoneal | 85mg/kg (85mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: COMA | Experientia. Vol. 41, Pg. 72, 1985. |
| mouse | LD50 | intravenous | 282mg/kg (282mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972. | |
| mouse | LD50 | oral | 10gm/kg (10000mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972. | |
| mouse | LDLo | subcutaneous | 200mg/kg (200mg/kg) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Proceedings of the Society for Experimental Biology and Medicine. Vol. 71, Pg. 544, 1949. |
| rabbit | LD50 | intravenous | 410mg/kg (410mg/kg) | Drugs in Japan Vol. -, Pg. 1409, 1995. | |
| rat | LD50 | intravenous | 500mg/kg (500mg/kg) | Drugs in Japan Vol. -, Pg. 1409, 1995. |
Safety Profile
Risk Statements: 33-62-68
R33: Danger of cumulative effects.
R62: Risk of impaired fertility.
R68: Possible risk of irreversible effects.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: LP5425000
F: 8
Specification
Folic acid , with CAS number of 59-30-3, can be called Pteroyl-l-glutamic acid ; pteroylmonoglutamic acid ; pteroylglutamic acid ; pteroyglutamic acid ; pteglu ; pga ; n-[4-[[(2-amino-4-hydroxy-6-pteridyl)methyl]amino]benzoyl]glutamic acid ; n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid . Folic Acid (CAS NO.59-30-3) is a toxic substance, with flammability, burning will produce toxic gases, so it should be stored in a tightly closed container which is cool, dry and well-ventilated, be away from incompatible substances and light. Dry powder, foam, sand, carbon dioxide, water mist can be used if something urgent happened.