Journal of Medicinal Chemistry p. 243 - 248 (1993)
Update date:2022-07-29
Topics:
Resul, Bahram
Stjernschantz, Johan
No, Kiyo
Liljebris, Charlotta
Selen, Goeran
et al.
A series of phenyl-substituted analoques of prostaglandin F2α (PGF2α) were prepared and evaluated for ocular hypotensive effect and side effects in different animal models.In addition, the activity of the analogues on FP receptors was studied in vitro.The results were compared with those of PGF2α and its isopropyl ester.The phenyl-substituted PGF2α analogues exhibited good intraocular pressure reducing effect, were more selective, and exhibited a much higher therapeutic index in the eye than PGF2α or its isopropyl ester.The analogues exhibited high activity on FP receptors in a stereoselective manner for the 15a-hydroxyl group.
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