Phenyl-Substituted Prostaglandins: Potent and Selective Antiglaucoma Agents

DOI: 10.1021/jm00054a008

Source and publish data:

Journal of Medicinal Chemistry p. 243 - 248 (1993)

Update date:2022-07-29

Topics:

Authors:

Resul, Bahram

Stjernschantz, Johan

No, Kiyo

Liljebris, Charlotta

Selen, Goeran

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00054a008

A series of phenyl-substituted analoques of prostaglandin F_2α (PGF_2α) were prepared and evaluated for ocular hypotensive effect and side effects in different animal models.In addition, the activity of the analogues on FP receptors was studied in vitro.The results were compared with those of PGF_2α and its isopropyl ester.The phenyl-substituted PGF_2α analogues exhibited good intraocular pressure reducing effect, were more selective, and exhibited a much higher therapeutic index in the eye than PGF_2α or its isopropyl ester.The analogues exhibited high activity on FP receptors in a stereoselective manner for the 15_a-hydroxyl group.

Full text of DOI:10.1021/jm00054a008

Products guided by the article

Product name:(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

Cas No:145773-20-2

R&D Labs maybe for 145773-20-2

Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China
Shanghai Profirst Co., Ltd.

Contact:+86-21-38122007

Address:2, Lane 1123, Kangqiao Road, Pudong New Area, Shanghai
Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI
shanghai Tauto Biotech Co., Ltd

website:http://www.tautobiotech.com/en/index.htm

Contact:+86-21-51320588 ext. 8025

Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA

Relevant to this article

Synthesis of Phosphonic Acid Derivatives by Oxidative Activation of Phosphinate Esters

Doi:10.1021/jo00254a015
(1988)
Lewis Acid-Catalyzed Nitrone Cycloadditions to Bidentate and Tridentate α,β-Unsaturated Ketones. High Rate Acceleration, Absolutely endo-Selective and Regioselective Reactions

Doi:10.1016/S0040-4039(00)74770-8
(1992)
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii

Doi:10.1021/acs.jmedchem.0c01535
(2020)
Dioxygen-triggered transannular dearomatization of benzo[5]helicene diols: Highly efficient synthesis of chiral π-extended diones

Doi:10.1002/anie.201400486
(2014)
Synthesis of 2,3-dihydro-3-hydroxy-2-hydroxylalkylbenzofurans from epoxy aldehydes. One-step syntheses of brosimacutin G, vaginidiol, vaginol, smyrindiol, xanthoarnol, and avicenol A. Biomimetic syntheses of angelicin and psoralen

Doi:10.1021/jo047974k
(2005)
Organocatalytic stereoselective synthesis of 3-alkyl-3-hydroxy-2-oxindoles catalyzed by novel water-compatible axially unfixed biaryl-based bifunctional organocatalysts

Doi:10.1002/cjoc.201400166
(2014)

Article Doi