
Tetrahedron Letters p. 215 - 218 (1993)
Update date:2022-07-30
Topics:
Paulvannan
Schwarz
Stille
The aza-annulation of an acyclic β-enaminoester with acryloyl chloride was found to be a very efficient method for nitrogen heterocycle formation. Stereospecific hydrogenation of the unsaturated dihydropyridone generated from aza-annulation gave a single disubstituted lactam product. The cis stereochemical relationship of the substituents was confirmed by transformation of the lactam to (±)-lupinine.
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