Bioorganic and Medicinal Chemistry Letters p. 1863 - 1868 (1997)
Update date:2022-08-03
Topics:
Yamada, Yasuki
Ando, Koji
Komiyama, Kazuya
Shibata, Saizo
Nakamura, Ikuro
Hayashi, Yoshiharu
Ikegami, Kiyoteru
Uchida, Itsuo
A series of low molecular renin inhibitors (molecular weight < 600) were prepared and their biological activities were evaluated. The inhibitors containing indole-2-carbonyl moieties at the P3 position and 2-amino-3,5-anti-diol fragment at the P1-P1' position showed renin inhibitory activities with IC50 of 10-8 M order and good blood pressure lowering effects after oral administration to sodium-depleted marmosets.
View Morewebsite:http://www.antaibio.com
Contact:86-21-60939051,60939771
Address:1518#,ZHANGYANG ROAD
Hangzhou Think Chemical Co. Ltd
website:http://www.thinkchem.com/
Contact:86-571-89986307/81956191/81956084/81956192
Address:Room 501-502, Tower E, Yuanjian Building, Yuanyang International Center, Hangzhou-310011, China
Contact:0571-
Address:zhejing
Huangshan Honghui Pharm Technology Co., Ltd.(expird)
website:http://www.honghuichem.com
Contact:18855958372
Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
Contact:0512-63006287
Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Doi:10.3184/174751913X13639769724276
(2013)Doi:10.1055/s-0033-1339312
(2013)Doi:10.1246/cl.1992.2419
(1992)Doi:10.1021/jacs.5b03074
(2015)Doi:10.1021/acs.jmedchem.0c01912
(2021)Doi:10.1007/BF00504421
(1985)