De novo design, synthesis, and X-ray crystal structures of pyrrolinone-based β-strand peptidomimetics

Article abstract of DOI:10.1021/ja00101a017

The de novo design and synthesis of a novel non-peptide scaffolding for β-strand/sheet mimics are described. The scaffold consists of repeating 3,5,5-trisubstituted pyrrolinone (enaminone) units punctuated with appropriate amino acid side chains. The iter