3-Ethenyl, 3-Ethynyl, 3-Aryl, and 3-Cyclopropyl-2,4,5-Trifluorobenzoic Acids: Useful Intermediates In The Synthesis Of Quinolone Antibacterials

Article abstract of DOI:10.1016/S0040-4039(00)60567-1

The synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2,4,5-trifluorobenzoic acids from 1-bromo-2,4,5-trifluorobenzene and 2,4,5-trifluoro-3-hydroxybenzoic acid is described.These compounds are useful intermediates for the synthesis of quinolon