Development of new 6-membered chelating chiral bisphosphine ligands for rhodium-catalyzed asymmetric hydrogenation

DOI: 10.1248/cpb.40.2921

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2921 - 2926 (1992)

Update date:2022-07-30

Topics: Synthesis Characterization Scale-up Publication and Patenting Design Motivation Catalytic Evaluation

Authors:

Inoguchi

Fujie Fujie

Yoshikawa

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.40.2921

A new chiral 1,3-bisphosphine, (1R,2R)-1-diphenylphosphino-2-(diphenylphosphinomethyl)cyclopentane, which was designed to form the favorable skew conformation of the six-membered chelate with rhodium, was developed. Its rhodium complex was found to be one of the most efficient catalysts known for asymmetric hydrogenation of amino acid precursors. Further improvement of this ligand was also attempted for catalytic asymmetric hydrogenation of prochiral ketones to clarify the enantioselective mechanism.

Full text of DOI:10.1248/cpb.40.2921

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Product name:(1R,2R)-1-(diphenylphosphinyl)-2-(hydroxymethyl)cyclopentane

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