New synthesis of substituted quinoline N-oxides via cyclization of alkylidene o-nitroarylacetonitriles

Article abstract of DOI:10.1055/s-1993-25781

Substituted quinoline N-oxides are prepareed via base induced cyclization of alkylidene derivatives of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by the Knoevenagel condensation.