Enantioselective and diastereoselective formation of syn-3-hydroxy-4-amino acids (syn-statines) via tetramic acids

DOI: 10.1055/s-1993-25834

Source and publish data:

Synthesis p. 216 - 220 (1993)

Update date:2022-08-06

Topics:

Authors:

Schmidt Schmidt

Riedl Riedl

Haas Haas

Griesser

Vetter Vetter

Weinbrenner

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Article abstract of DOI:10.1055/s-1993-25834

Enantiomerically pure pyrrolidine-2,4-diones (tetramic acids) which can be diastereoselectively hydrogenated to syn-statines (4-amino-3-hydroxy-6-methylheptanoic acids) have been prepared by catalytic hydrogenation of 4-(benzyloxycarbonylamino)-3-oxocarboxylic acid esters.

Full text of DOI:10.1055/s-1993-25834

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