Tetrahedron p. 3707 - 3722 (1997)
Update date:2022-09-26
Topics:
Verardo, Giancarlo
Toniutti, Nicoletta
Giumanini, Angelo G.
N-Substituted 1,4,5,6-tetrahydropyridazines (3) can be prepared in a one pot procedure from a hydrazine 1 and 2,5-dimethoxytetrahydrofuran (2) using NaBH4 in aqueous-THF acidic medium in fair yields, Variable amounts of two side products are also formed: hexahydropyridazines 5, likely produced by a route other than the direct reduction of 3, and 1-aminopyrrolidines 4. A direct reduction-N-reductive ethylation of3 could be achieved in AcOH with NaBH4..
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