Pyridazine derivatives. XI: Antihypertensive activity of 3- hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives

Article abstract of DOI:10.1002/jps.2600820314

3-Hydrazinocycloheptyl[1,2-c]pyridazine (4) and its hydrazone derivatives 3-[N¹-(isopropylidene)]hydrazinocyclohexyl[1,2-c]pyridazine (5) and 3-[N¹- (isobutylidene)]hydrazinocycloheptyl[1,2-c]pyridazine (6) were prepared, and their activity against genetic, neurogenically-induced, and deoxycorticosterone acetate -NaCl-induced hypertension was found to be at least as great as that of hydralazine. The results of studying vasorelaxation of rat aorta by 4 and hydralazine suggest that both these compounds owe their antihypertensive activity to direct relaxation of vascular smooth muscle.