Palladium catalyzed cross-coupling reaction between 3-indole boronic acids and tetrahydropyridine triflates

Article abstract of DOI:10.1016/S0040-4039(00)77582-4

The palladium catalyzed cross-coupling reaction between 3-indole boronic acids and vinyl triflates is a good method to introduce vinyl groups into the indole 3-position. The regioselectivity of the enolization of N-substituted-3-piperidones is far greater than previously reported. N-tosyl-3-indole boronic acids can be easily synthesized via mercuration-boronation method.