
Tetrahedron Letters p. 2461 - 2464 (1993)
Update date:2022-08-03
Topics:
Mora, N.
Lacombe, J. M.
Pavia, A. A.
Several phosphoserine and phosphothreonine synthons suitable for the stepwise synthesis of phosphopeptides have been prepared.Treatment of methylthiomethyl (MTM) esters of either benzyloxycarbonyl (Z), tert-butyloxycarbonyl (Boc) and allyloxycarbonyl (Alloc) serine and/or threonine with phosphochloridate in pyridine, followed by MgBr2 cleavage of MTM in diethylether, afforded the title compounds in excellent yields.
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Doi:10.1039/c3cc48813f
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(1973)