Synthesis, characterization and biological activity of (Z)-1-[2]-1-cyclopentanol and their arylhalostannyl derivatives

Article abstract of DOI:10.1016/S0277-5387(98)00027-8

The synthesis and characterization by elemental analysis, IR and ¹H NMR of (Z)-1 - 1-cyclopentanol,CH₂(CH₂)₃C(OH)CHCHSnPh ₃ (1) and (Z)-1 - 1-cyclopentanol, CH₂(CH₂)₃C(OH)CHCHSn(p-toly)₃ (2) are described, together with their halodemetallation by I₂, Br₂ and ICl to yield derivatives of the types CH₂(CH₂)₃C(OH)CHCHSnAr_3-nX _n (Ar = phenyl or p-tolyl ; n = 1, 2 ; X = I, Br, Cl). The solid-state structures of two compounds have been determined by X-ray diffraction analysis. In the crystal of CH₂(CH₂)₃C(OH)CHCHSnph₃ (1) the Sn atom has a distorted tetrahedral geometry but intramolecular contact with the hydroxyl O atom has not been found. A trigonal bipyramidal geometry is found in CH₂(CH₂)₃CC(OH)CHCH SnphBr₂(11), in which OSn - interaction is noted [2.446(8) A] The biological activity of the title complexes is also investigated.