A versatile synthesis of β-amino acids using the Nicholas reaction. I. Application to β-lactams of the carbapenem class

Article abstract of DOI:10.1016/S0040-4039(00)77630-1

Homochiral acetylenic acids of general structure 10, prepared using the Schreiber modification of the Nicholas reaction, have been converted to β-amino acid derivatives of type 11 by a two step sequence involving Curtius rearrangement followed by oxidativ