A versatile synthesis of β-amino acids using the nicholas reaction. II. Formal total synthesis of thienamycin

Article abstract of DOI:10.1016/S0040-4039(00)77631-3

Homochiral acetylenic acid 26, prepared using the Schreiber modification of the Nicholas reaction, has been converted to β-amino acid derivative 28 by a two step sequence involving Curtius rearrangement fallowed by oxidative clevage of the acetylenic bond