Renin inhibitors containing a pyridyl amino diol derived C-terminus

Article abstract of DOI:10.1021/jm00071a009

Based on the concept of transition-state analogs, a series of nonpeptide renin inhibitors with the new (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy- 6-(2-pyridyl)hexane moiety at the C-terminal functionality were synthesized and evaluated for inhibition