Journal fur Praktische Chemie - Chemiker-Zeitung p. 332 - 336 (1993)
Update date:2022-08-03
Topics:
Hillner, A.C.
Jans, A.W.H.
Winkel, C.
The first regio- and stereospecific synthesis of S-(-)-13C-malic acid 5 with a high incorporation of 13C and excellent enantiomeric excess is described.S-(-)-13C-malic acid 5 was synthesized in a three-step reaction starting with ethyl acetate 2 and diethyl oxalate 1.The produced sodium diethyl oxaloacetate 3 was then enantioselectively reduced with bakers yeast to S-(-)-13C-malic acid diethylester 4 which was hydrolyzed to S-(-)-13C-malic acid 5.
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