ChemCatChem p. 2425 - 2431 (2014)
Update date:2022-09-26
Topics:
Brenna, Elisabetta
Crotti, Michele
Gatti, Francesco G.
Manfredi, Alessia
Monti, Daniela
Parmeggiani, Fabio
Santangelo, Sara
Zampieri, Davila
The enantioselective reduction of α-methylene nitrile derivatives catalysed by ene-reductases affords the corresponding (R)-2-arylpropanenitriles with high conversion values. The reaction is investigated either in aqueous medium (with an organic cosolvent or by loading the substrate onto hydrophobic resins) or in a biphasic ionic liquid-water system. The use of ionic liquids, herein with isolated ene-reductases, is found to improve the work-up and the substrate recovery method. The synthetic manipulation of the final chiral nitrile derivatives indicates how this biocatalysed method can be exploited for the preparation of a wide range of chiral compounds.
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