Synthesis and assay of hybrid analogs of argiotoxin-636 and philanthoxin-433: Glutamate receptor antagonists

Article abstract of DOI:10.1016/S0040-4020(01)87944-8

The synthesis of the non-competitive glutamate receptor antagonist, argiotoxin-636 is described. Furthermore, synthetic routes are presented for the preparation of structural analogs including argiotoxin-philanthotoxin hybrids. Biological activities on gl