Microbial reduction of 2-keto acetals as biocatalytic approach to the enantioselective synthesis of optically active 2-hydroxy acetals

Article abstract of DOI:10.1016/S0957-4166(00)80434-6

The reduction of the 2-keto acetals 1a and 1b by means of different microorganisms constitutes the biocatalytic access to optically active (46 to 100% ee) 2-hydroxy acetals, (S)-2a or (R)- and (S)-2b, representative compounds of a class of synthetically useful chiral building blocks.