Synthesis and biological activities of meribendan and related heterocyclic benzimidazolo-pyridazinones

DOI: 10.1016/0223-5234(93)90005-Y

Source and publish data:

European Journal of Medicinal Chemistry p. 129 - 140 (1993)

Update date:2022-08-02

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Authors:

Jonas, R

Klockow, M

Lues, I Lues, I

Pruecher, H

Schliep, H J

Wurziger, H

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Article abstract of DOI:10.1016/0223-5234(93)90005-Y

The synthesis of a new heterocyclic benzimidazolo-pyridazinones is described.The new compounds were evaluated as inotropic agents with 'calcium-sensitizing' effects. 5-Methyl-6-<2-(3-pyrazolyl)-5-benzimidazolyl>-2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope. benzimidazole / calcium sensivity / cardiotonics / inotropes / phosphodiesterase / papillary muscle / pyridazinone

Full text of DOI:10.1016/0223-5234(93)90005-Y

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