European Journal of Medicinal Chemistry p. 129 - 140 (1993)
Update date:2022-08-02
Topics:
Jonas, R
Klockow, M
Lues, I
Pruecher, H
Schliep, H J
Wurziger, H
The synthesis of a new heterocyclic benzimidazolo-pyridazinones is described.The new compounds were evaluated as inotropic agents with 'calcium-sensitizing' effects. 5-Methyl-6-<2-(3-pyrazolyl)-5-benzimidazolyl>-2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope. benzimidazole / calcium sensivity / cardiotonics / inotropes / phosphodiesterase / papillary muscle / pyridazinone
View MoreSHANGHAI SYSTEAM BIOCHEM CO., LTD
website:http://www.systeambc.com
Contact:86-021-58380978
Address:Building 87，Lane 669， Dong Jing Road Shanghai,P.R.China
Jiangsu Cale New Material Co.ltd
Contact:+86-515-88334667/88203550
Address:Zhongshan 3rd Road, Coastal Chemical Industry Park, Yancheng, Jiangsu, China
Fuxin Jintelai Fluorin Chemical Co., Ltd.
Contact:+86-0418-8229599
Address:, 7th Huagong Road, Fluorine industry development zone (Yimatu Town,Fumeng County),Fuxin City, Liaoning Province, China
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
Zibo Ocean International Trade Co.,Ltd(expird)
Contact:+86 533 5160706
Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Doi:10.1016/S0020-1693(00)84790-8
(1981)Doi:10.1055/s-0035-1561574
(2016)Doi:10.1016/S0040-4039(00)60637-8
(1993)Doi:10.1039/c4cc08829h
(2015)Doi:10.1021/ja963113k
(1997)Doi:10.1080/00397911.2013.769601
(2013)
